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英文名字 Cell Permeable Rho Inhibitor (C3 Trans based))
中文名称 细胞渗透性 Rho 克制剂(基于C3转移酶)
供给商 Cytoskeleton
产品货号 CT04-XL
产品报价 ¥询价/LargeQuantities
购置方法 Cytoskeleton中国区现货中心已经建立,大部分产品中国有现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话接洽400-6800-1072
产品消息
背景材料 待更新
产品描写 This product consists of highly purified C3 Transferase (Cat. #CT03) covalently linked to a proprietary cell penetrating moiety via a disulfide bond. The cell penetrating moiety allows rapid and efficient transport through the plasma membrane. Once in the cytosol, the cell penetrating moiety is released, thereby allowing C3 Transferase to freely diffuse intracellularly and inactive RhoA, RhoB, and RhoC, but not related GTPases such as Cdc42 or Rac1.The Exoenzyme C3 Transferase fromClostridium botulinumis commonly used to selectively inactivate the GTPases RhoA, RhoB, and RhoC, bothin vivoandin vitro. C3 Transferase inhibits Rho proteins by ADP-ribosylation on asparagine 41 in the effector binding domain of the GTPase. A major limitation of C3 Transferase for use inin vivoapplications is that this protein is only slightly cell permeable. Consequently, overnight incubations with C3 Transferase at concentrations as high as 100 g/ml are often necessary to inactivate Rho proteins in cultured cells. Under these conditions, the long incubation period and large amount of C3 Transferase that are required can be disruptive to basic cellular functions and economically burdensome. Cytoskeleton, Inc. has overcome these problems by providing a cell permeable form or C3 Transferase that can efficiently inactivate cellular Rho proteins in as little as 2 h.
产品情势 待更新
产品阐明书
其他 Cytoskeleton公司成立于1993年,专注于生物化学和细胞过程研究中的纯化蛋白和便捷试剂盒开发与生产。公司供给药物筛选、信号转导、蛋白质转录后润饰(PTM)、细胞骨架研究相干的系列试剂盒和产品,尤其以细胞骨架相干研究见长,既能满足于样品较少的科学研究,也可以用于小规模筛选研究和高通量大规模筛选研究。此外,公司还供给微管蛋白,肌动蛋白,小G蛋白,GAPs,GEFs等现有产品的药物筛选服务。

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